The Critical Micelle Concentration (CMC) is the surfactant concentration at which micelles begin to form in solution. Above the CMC, these micelles encapsulate hydrophobic drug molecules, dramatically improving solubility and dissolution. For sodium lauryl sulfate (SLS), the CMC in pure water at 25 °C is approximately 8.2 mM . Practical Example: In ezetimibe tablets, introducing…
In pharmaceutical development, a drug’s success depends not only on its formulation but also on how efficiently it reaches the bloodstream. One of the most critical yet often overlooked factors? Dissolution testing and its direct impact on pharmacokinetics (PK). What’s a Dissolution Profile? Dissolution testing simulates how a tablet releases its active ingredient in the…
What is a Discriminatory Medium? A discriminatory medium in biopharmaceutical studies is a dissolution medium that can effectively differentiate between formulations based on their in vitro drug release characteristics. It is designed to highlight differences in formulation, process variables, or drug substance properties that may impact in vivo performance. Why is a Discriminatory Medium Important?…
Tablet dissolution is a critical process in pharmaceutical sciences, influencing drug bioavailability and therapeutic effectiveness. This review explores the principles of tablet dissolution, detailing the key stages from administration to absorption. It also discusses factors affecting dissolution, analytical methods, regulatory considerations, and emerging technologies shaping the future of drug release and bioavailability enhancement. Oral solid…
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