Drug Delivery System

Osmotic Pump Extended-Release Technology for Oral Dosage Forms

Osmotic Pump Extended-Release Technology for Oral Dosage Forms

Oral drug delivery remains the most convenient and preferred route of administration. However, conventional oral dosage forms often face challenges such as fluctuating drug plasma levels and poor patient compliance. Extended-release formulations, particularly osmotic pump systems, have been developed to overcome these limitations by providing a consistent and controlled release of the drug. Osmotic pump…

Glass Transition Temperature and Drug Release from PLGA-Based Microspheres
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Glass Transition Temperature and Drug Release from PLGA-Based Microspheres

Poly(lactic-co-glycolic acid) (PLGA) is a widely used polymer in drug delivery systems, particularly for creating long-acting injectable microspheres. A crucial factor influencing the drug release profile of these formulations is the glass transition temperature (Tg), which represents the temperature at which PLGA transitions from a hard, glassy state to a softer, rubbery state. Impact of…

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