Predicting Dissolution via the Critical Micelle Concentration (CMC)
The Critical Micelle Concentration (CMC) is the surfactant concentration at which micelles begin to form in solution. Above the CMC, these micelles encapsulate hydrophobic drug molecules, dramatically improving solubility and dissolution. For sodium lauryl sulfate (SLS), the CMC in pure water at 25 °C is approximately 8.2 mM . Practical Example: In ezetimibe tablets, introducing…
